Hands down, my favorite restaurant in Las Vegas. I've been there 5 times now and have left completely satisfied each time. The restaurant itself is beautiful and has indoor and outdoor seating as well as an indoor and outdoor bar. Since Brio doesn't take reservations, you'll often have to wait a good 30-45 minutes which is plenty of time to get yourself is peach bellini (yes, it's girly and frothy) which is wonderfully refreshing and not too sweet. The waiters are all very attentive, even when the place is slammed, which is a nice change from the LV norm.
Food wise: the bread you're served upon seating is piping hot and delicious; the lobster bisque is amazing; the brio chopped salad is great (but I recommend getting the balsamic dressing over the red wine); caprese bruschetta is delicious, as is the roasted red pepper brushetta (blanking on the name); and those mini desserts (creme brulee especially) are the perfect endings to a great meal.