I did not stay here (stupid me) but I spent time in the casino and walking around the hotel. And I can tell you that hands down this place beats the Venetian in terms of atmosphere, environment and service. Here's why:
The Wynn Casino was not smoky and disgusting like the Venetian. There lots of non-smoking tables and the place felt really clean and open and not cramped at all. Pleasant even. Plus, the dealers were all incredibly friendly and sweet, as were the pit bosses/managers. I got over my fear of single deck black jack here and cleaned up, yo!
Plus the cocktail waitresses actually came around and gave me drinks almost twice as much as I got when in the casino at The Venetian where the cocktail waitresses were never around and seemed only interested in men when they did come by.