If you're in Cleveland, you have to go to Melt. It's a rule.
The menu has changed for the worse over the last few years, but it still towers above all competitors. Every possible option is big, delicious, and distinctly local. The staff is fantastic (after a handful of visits, they started calling my wife and I by name), and the food is both distinctly American and urbanely weird.
Expect it to be busy, but give it a visit. You won't be disappointed.