I am a big fan of Venetian. This is my first-choice for my trips to Las Vegas.
During my last visit, my usual tip at the front desk yielded me a Rialto suite with a pool view. 1100 square feet? Yes please.
One thing I like the most about this hotel (which ironically could be deal-breaker for some) is the scent. They must pump gazillion amount of air freshener into the ventilation system because it actually smells "good" (again, subjective) just about everywhere.
Amenities and services are top-notch, as you would expect from hotel of this caliber. Another major plus in my book is the poker room at Venetian. They give you Fiji water! No more crappy casino-branded bottle water! Yay!
Obviously not for those on a budget, but definitely worth it if you are willing to spend a little.