I've been here a few times and it's always been really enjoyable. The cocktail menu is serious but the servers are very knowledgeable and helpful if you need some ideas. The cocktails are moderately priced and many of the liqueurs used are made in house. I love a good gin cocktail and highly recommend The Wibbley and their version of a Corpse Reviver. The food menu is small but has good variety; they stop serving their full menu after 11pm and switch to a late night menu. I love the green chile mac n cheese, anything with the noble bread, and I just had the yum yum noodles with pork belly, which was very tasty.
I have to say Bitter and Twisted is the best cocktail bar I've been to in downtown Phoenix. The only downside is actually getting into the bar. You have to wait outside while they make sure a table is available. I've never had a problem getting a table on a Friday but Saturdays can be very busy.