Ambiance: 4. Let me start by saying I never frequented the old Barcelli Inn at this location. That said, loved the modern but cozy plantation-like feel. Open air kitchen you walk by on the way to tables is a nice touch, especially reassuring for those of us that have seen the movie Waiting. One note -- there's various rooms so if you like a certain dining experience you need to call ahead and ask for that (quiet, outside, larger room, etc.). However, the distance from main drag of Little Italy and area surrounding it leaves something to be desired, and would be the likely reason I don't return on a regular basis.
Cost: 4. Most appetizers were slightly pricey in my opinion, BUT portions were generous. As far as meals go typical mid to high end restaurant with ~$20 meals but a little higher after including sides and/or salad.
Food Quality: 5. Local sourcing, good variety but not too many items that you think they're just using a all encompassing cookbook. Appetizers outshined the main meal slightly (calamari featured very light and fluffy breading, while the shrimp and grits was also something special), but still I enjoyed the perch & lobster cake special I had. Another in our party commented the Mahi Mahi was outstanding.
Service: 5. Waitress was great, bus staff excellent as well -- constant water refills (a key myself) and did not rush to take our plates away. Oh, and the waitress actually knew something about menu when we asked questions.
When to return: Any and all. Great for happy hour, summer time (great patio), special occasions (secluded rooms) and dates.