Mandalay Bay is easy to Spot on the Strip with its bright gold buildings located on the very Far South end of the strip. It's close access to the airport and rental car center but it's not in the heart of the strip.
Regardless, being a Four Seasons Hotel should say enough in that this hotel is all about high class and luxury. The rooms are spacious and filled with all the high quality amenities you would expect from a hotel of this caliber but for me, that's not the best part.
Mandalay Bay has a whole host of clubs and bar areas with a variety of live music. On any given night, there are many (3 or 4) different live music venues within the hotel and don't forget about House of Blues as well. When I want to hang out, have a few drinks and relax in a safe, upscale environment (without hundreds of 20 somethings jumping around to techno music), Mandalay Bay becomes my sanctuary.
If you want to visit the Luxor or Excalibur you can do so very easily by jumping on the tram that goes between the three hotels (for no charge).
Enjoy!