I've taken my laundry to the Laundry Factory a couple of times now. They are always prompt and do a good job at taking care with your clothes. The place is surprisingly clean and bright for a laundromat.
As Zoe mentioned the prices are very reasonable and you won't find a cleaner place anywhere near Shadyside. Another plus, when I needed somethings turned around quickly they were more than willing to accommodate me, for no extra charge.