This is my favorite place to stay when in Vegas for a variety of reasons. First and foremost, the pools at the Wynn and Encore (you have access to both) are basically perfect vacation pools - happening scene, respectable clientele and friendly service. The casino is clean and well ventilated, the air seems fresh and there were never issues finding a suitable blackjack table. There are several good dining options on-site, as well as some very swanky nightclubs that were quite popular. If you plan to visit one of the clubs, I suggest speaking to a guest host about your admission options (lines can be very long). The golf courses are immaculate. The rooms are modern and bright with great views through windows that span the entire width of the exterior wall. My only complaint is that because of the hotel's popularity, you can frequently run into crowds.
Oh, and the Peppermill Restaurant is nearby, the perfect offsite spot for a great breakfast.