If it is your first visit to Vegas and you are looking for a typical crazy Vegas experience, you might want to stay somewhere more centrally located on the strip. Although, I may need to take that statement back after the whole Prince Harry fiasco at the Wynn a couple weekends back. This may, actually, now be THE place to stay for a crazy, messy Vegas weekend.
In all seriousness, I loved the Encore because it was slightly off the strip, a bit away from all the action, and I had been to Vegas a million times and just didn't need THAT. You could obviously still stay here and cab it over to the center of the strip to go out, but if you are trying to avoid that, this is a great place to do it.
The rooms are beautiful and spacious but do not be fooled by the word "suite". We had a "suite" at the Encore and a "room" at the Wynn and the two were pretty much the same, although the room at the Wynn was definitely less expensive. The bathroom is my dream bathroom. Seriously, one day I want to build a bathroom in my house mirrored after it. There is a large tub and shower with two sinks and a vanity, and a TV on the wall so you can watch TV while getting dressed. The toilet is separated within the same room, so you could have someone in the toilet while someone else is doing their makeup.
The pool is the best on the strip, especially the European Pool which is 21+. It is a topless pool, but about .005% of the women are actually topless.
Super classy hotel.
I agree with others that say that it is nicer than the Bellagio, but I gave both equal stars because the Bellagio has that killer location in the center of the strip.