One of the best places to stop for coffee downtown. I used to work in the area for man years and I stopped in here every day for a cup of coffee.
It is located in the lobby of the Regional Enterprise Tower (formerly known as the Alcoa Building) and is almost easy to pass by if you're in a hurry. It is a great spot to grab a cup of coffee to go if you're in a hurry (if that's your thing), but I'd much rather grab a mug and sit in the lobby for awhile.
They offer coffee of all kinds, smoothies, juices, pasties, and often times pre-made sandwiches or fruit cups.
The staff is friendly and the owner, Ward, is one of the most enthusiastic coffee guys you'll meet in Pittsburgh. He is very passionate about his place and the things on the menu.
Although it is known as a cafe interested in local, organic, and fresh ingredients, it definitely doesn't have the pretentious vibe you may relate to that.
I recommend Simpatico to anybody in the downtown area, whether you're just looking for a quick coffee or smoothie to go, or looking to hang around and have some great coffee conversation!