We typically come to Vegas on the weekend and if we're staying on the strip, which we usually do, so we come here.
Very easily accessible going northbound on the strip if you have access to a car, and even the other way it's not too hard to get in, and parking is typically pretty open. Other than that, you can walk from most hotels on the center strip and can catch a cab for a decent fare if you so wish.
Came here on Easter weekend once, and the place was so packed that they had to set up speakers outside for those who could not find space in the Church. Other than that, Sunday mass is not too crowded. We've even gone to daily masses here, and there are a few locals, or at least they look like locals, attending.