On making reservations:
It can be ambiguous and quite a challenge. It took 2 trips to Vegas for the stars to finally align for me to finally be able to get in. They have 2 seating a night and they seat about 10 people inside a separate room in Jaleo at the Cosmopolitan. You must email them exactly one month in advance at midnight Vegas time, which means if you are traveling from the east coast set up an email rule to send your email at 3:01AM. Also have several dates and times that you are available to increase your chances of getting in.
On the dining experience:
I dined here on a Sunday evening after a monster weekend in Vegas. This is definitely a social experience with the other diners sitting around the bar style seating. I felt just as comfortable dining here solo as I would with a date. About half the group were actually solo diners. Our group was young, funny, and very social. Don't feel pressured to do the wine pairing, although I heard it was excellent only 2 or 3 of the diners in our group did it. Plus we were greeted with a glass of champagne when we sat regardless of whether you ordered the wine pairing and one of the dishes was, as I would describe it, a large sangria caviar. So there is enough alcohol served if you wanted to drink light.
On the show:
The show here is the two chefs in action. Most of the dishes have been prepared somewhat in advance, but they are assembled and discussed right in front of your eyes. Some of the dishes came off like alchemy. Feel free to ask any questions you want, they are happy to discuss the dishes in detail. The 2 chefs/wizards said it takes 36 man hours to prepare for each service.
Normally I would go into detail about each dish but there were just too many and you don't have a choice in what you eat. You just get to try everything. The dishes ranged from good to amazing. I've been to a handful of places that I would say had better food, but the presentation and creativity at work here is unmatched. On my visit it cost $199 + tax, I was told there was no tipping even after insisting. If you are interested or curious about molecular gastronomy then it is worth the visit. If like me the high price is tough to swallow, do what I did, look at it as a great Vegas show instead of a dinner you won't regret it.
*Posted are a picture of the golden ticket you get when you make a reservation, their menu you get to take home, and a few of the dishes.