I tend to go more for the independently owned breweries, but I enjoy Rock Bottom. As with any large chain, I suggest sticking to the seasonal beers made available, as they tend to have more character and depth than the standard fare offered every day. But your mileage may vary.
Looking for an appetizer? Go with the pretzels. You won't be disappointed. My wife is a fan of their Grilled Salmon Caesar salad. Me? I tend to pick whatever is on special. The "fireman pizza" (or whatever it was called) was rather uninspiring.
All and all, a solid place for a good meal and brew.