Every time we are in Vegas, we eat here. It is one of the three or four restaurants that he HAVE to go to. I've taken several family members and they have all loved it.
The meat lasagna is the best I have ever had! Lots of meat and stringy cheese and a wonderful meat sauce that covers it. The flavor is fantastic. Another great option is their Shrimp Joe. It's pasta with garlic oil, pepper flakes, shrimp and fresh mushrooms. It is strong on the garlic, so be warned that you will be tasting it for hours after you eat. They also have a great spaghetti and meatballs. I know! You can make spaghetti at home, so why order it at a restaurant? It's the meatballs and sauce that makes it SOOO GOOD!
Most the meals come with a salad or soup. The cream garlic salad dressing is fantastic. The only down side is the salad itself - just basic iceberg lettuce mix. I wish they would use a spring mix or romaine lettuce. The bread is very good and fresh and the servers have been friendly.
The only problem I can think of about Chicago Joe's is the location. It's in a somewhat rough part of town in between the Stratosphere and downtown Las Vegas. You might not want to be here too late at night. Otherwise, I highly recommend this place.