-heavy sigh- I fly through Charlotte a lot since it's one of two connections to my home airport. I have no other options ... Okay, Charlotte isn't THAT BAD. It really isn't bad at all. Spacious airport with lots of places to sit and eat and shop. Everything you didn't know you needed in an airport. They keep it clean and tidy and the bathrooms are decent. I don't know much about TSA since this is my connection airport, so I'll let other Yelpers chat about that.
However, when purchasing tickets and finding out your layover is in Charlotte, don't try to save time by getting the flight with the smallest layover. I DO NOT RECOMMEND THIS. As another Yelper mentioned, there are no shortcuts. I mean, if you manage to snag a ride on the multiple carts going by, good on you, but you know good and well that your legs are working and you need to walk. Wear comfortable shoes because it'll take you some time to get from terminal to terminal.
Make some trams or something. Please!