The Omni William Penn put us in the middle of everywhere we wanted to be in Pittsburgh - PNC Park, Duquesne Incline, Andy Warhol Museum, and all the amazing architecture was within walking distance. We had a view of the UPMC Building from our room.
The hotel itself is beautiful. Service was quick and always friendly. The gym was a lot bigger than other hotel gyms I've been in. The room was clean. The bed was comfortable. The nightstands had outlets in them. No complaints, 5 stars all the way around. I'd stay here again in a heartbeat.