Spadina Station is a great crossroads for transportation in the city.
From here you can access both north/south and east/west subway lines, plus connect to the Spadina Streetcar.
Note - if you are lazy and need to change from one line to another, it's best to do this at St George Station. It can be done from Spadina, but you will need to walk down a very long corridor to switch lines. At St George you just walk up or down 2 flights of steps.
The streetcar access here is fab as you can hop on without going outdoors. The track comes straight underground and collects you.
Spadina station gets busy but never as crazy as Yonge/Bloor (ugh)