Uncle Otis carries a great quality line of clothes which are modern, urban and tasteful. The prices may seem high, but you get what you pay for and they decent sales once in a while.
The staff is especially friendly, down to earth, helpful and very knowledgable.
They give great opinion and advice, especially when it comes to fit. Also they will give washing and care instructions to each piece of clothing you purchase, which I though was thoughtful and shows the pride in their inventory.
They have a very nicely designed store and doesn't feel stuffy or pretentious as other stores in the area.
Some of the European lines do run rather large in sizing, but most of their staples like their jeans has sizes that will fit most.
I prefer to get my jeans and pants here over Over the Rainbow, which I don't particularily enjoy shopping there.