I'm ashamed to admit I'm a fan because I do try to get all of my clothes from thrift stores. That being said, the thrift stores in central Illinois just aren't that great. Unless you have a lot of luck (which I don't) it's really difficult to dress yourself well if you just shop second-hand in Champaign-Urbana.
What others have said about Urban Outfitters being hipster in a box is true and it is overpriced. It's weird because they seem to cost more than their locations in Chicago and St. Louis but maybe that's because I shop sale and there's more sale items in the bigger stores? Nonetheless for central Illinois they do have a lot of unique stuff and if hunt through the sale you can find things at decent, and sometimes even cheap, prices.
On a final note, there's a lot of yappy annoying undergrads that flock to Urban Outfitters on the weekends so try to go on off hours.