This is one of my favorite shops to hit up when I'm walking the Strip.
I was initially hesitant to go to Penzeys because the storefront looks so upscale I thought I would never be able to afford anything they sell. Boy, was I wrong. Their prices are CHEAPER than Giant Eagle and they have a MUCH better variety. Not to mention that they are fresher and local. Oh, and if you sign up for their mailing list, they'll send you coupons -- I've gotten several for FREE 1/2 cup sized jars of spices! The coupons come attached to a catalog that is packed with delicious recipes -- we've tried four or five and they don't disappoint.
Inside the store, almost every shelf has a covered container of spice so that you can smell them yourself before purchasing, so Penzeys always smells good. And the selection of spices is A-MAZING. I've never seen anything quite like it. So many different varieties of common spices, and LOTS of uncommon ones.
They have a great baking section, so if you enjoy baking as much as I do, you can find all sorts of flavorings and extracts and specialty sugars and cocoas here.
The staff is knowledgeable and friendly, too -- so don't be afraid to ask a question!