The newest club in Vegas and I had a great experience.
Anywhere in Vegas even if you're on "guest list" the guest list line will always be a mile long while the general entry line has no line. To avoid this:
1) go really early (say 9pm)
2) pay the general entry cover (discount if you're on guest list)
3) pre pay your tickets
There are two rooms in Omnia; the Heart which is hip hop and the main room which plays EDM and an outdoor terrace. I spent my night in the main room because there was more space. The venue doesn't allow e-cigarettes but allows smoking. Go figure. Drinks can be definitely pricey.
What was really cool about this place is on the main floor the chandelier and circular globe goes up and down and can be triply. The venue is beautiful and so spacious. You'll love it.