I did this run yesterday (I did the 1/2 marathon) and there were definitely things I liked and things I did not like.
Pros:
1) awesome and unique course - running down the Las Vegas Strip at night is amazing!
2) late afternoon start time (perfect for those of us who do not normally get up before 8am and do most of our running in the evening)
3) THE COURSE IS COMPLETELY FLAT!
Cons:
1) weird ghetto part of the run around the half-way point that was dark and lit by random floodlights
2) a bit of chaos at the start line (you could go with any corral you wanted to, and people did)
3) the race is Sunday evening - so it's kind of hard to enjoy a weekend in Vegas when you know you're doing a long-distance endurance event at the end of it.
4) expensive compared to other events
Overall, recommended - pretty cool to run down the Strip at night. Will do again!