I've been coming to Skeptical Chymist for several years and I am almost always extremely happy with the experience. My husband and I typically like to go when they're having their "Pub Quiz" trivia night each week and we have also visited during special holiday events (St Paddy's Day, etc;)..
Service is always friendly.. I have waited a little too long on busier nights, but I chalk that up to being in a crowded bar with people shouting out questions to the trivia caller. It is a bit chaotic, but not uncomfortable and I've never had bad or rude service from the waitstaff or the bar.
The food is tasty! There is a plentiful selection of plenty of typical bar food and they pull it off easily.. They also have a nice offering of Irish-inspired choices and what we've sampled have all been very good. The prices are quite reasonable and there is a different drink special every night - sometimes beers, sometimes cocktails - so our bill is never "too high".
The decor inside is really fantastic. They've taken on the idea of a classic Dublin apothecary (with one side larger room that would be good for daytime lunch meetings styled as a library).. It is dark with plenty of tables and chairs and it is kept comfortably cool inside (but not freezing). The patio is well lit and clean, so it's a nice place to wander during the nicer Arizona months.
Overall, I greatly enjoy my visits to Skeptical Chymist. It's more interesting than your average bar/pub and the food is definitely fresher than anything you'll find at the average chain.