I go here to treasure hunt for craft supplies, furniture, and appliances. Out of all the other locations that I've tried in Charlotte, this Goodwill has the best non-clothing selection. If you want clothes, I would recommend the Ballantyne location.
The local Rivergate stores, most notably Target and Home Depot, donate often to this store which makes for some really amazing deals on new products. Many offices and schools also donate to this store so you will find office products and furniture on a regular basis.
For the Senior Citizen crowd, Tuesdays you get a better deal than the employees do - 25% off everything. I keep trying to get an old lady to adopt me but so far it's a no go.