I had he misfortune of living in the Bay Area for 6 years. Ike's at Stanford was one of the only good things about it.
From what I understand, Ike's has developed thousands of sand which combinations over the years. My personal favorites are the Damon Bruce and the Reggie Jackson (you'll notice that the sandwiches are typically named after someone, lots of sf giants players on the menu).
This place just opened in an odd corner of Mesa on valentines day. The best thing about it is there was no line and no San Francisco people that you had to deal with in order to get a great sandwich.