Best advice especially if coming with kids- plan ahead parking and eating options. Its very busy and easy to get disoriented in a crowd of 30,000! Dont miss the opportunity to see new things and connect with the Arts Community Downtown. I personally always stay by the 18b area so i can walk around to find special pop up galleries. These are 1 of type showings for First Friday and can even be in private homes! I have also really enjoyed the experience a vendor too. Artists rates are super resonable.
Not to miss:
Amanda Harris Gallery in Soho lofts
Eva Steil (photography usually at Blackbird Studios)
Mingo
"Green Street" on California & Casino Center