A local favorite. Fantastic selection of beer on tap all brewed on premises. Try the Scotch Ale, the American Pale Ale, and the Crop Circle Wheat or just get the sampler. Also, above average bar food, pretty decent Friday night fish fry, and six high quality pool tables.
Be warned: the Great Dane can sometimes be a victim of its own success. On a Friday or Saturday night, the place can be packed and very loud. Check out the rathskaller or the beer garden to avoid the crowds.