Asking around Vegas what the hottest club is at the moment, most people said, "Tryst!" The place is packed to the walls until closing, which unlike SF is 4am-ish. Decent mix of hip hop and dance hall while we were there. People here were dressed to impress and you can't beat the outdoor patio area with the waterfall. The inside is laid out in 3 lounge areas with a main dance floor that leaks out to the patio. There are a lot of drunk, rude-ass people that constantly bump into you on the dance floor, but it could be like that at all clubs in Vegas.
It does pays to stay at the Wynn because we were taken past the line like freakin' VIPs just by flashing your room card.