How could you not love Tryst?! It is pretty much the original "super club" in Vegas and still goes hard.
I love the layout - the club is spread out well, with both indoor and outdoor space, opening out to the large waterfall. I do think the dance floor is pretty small, and it gets crowded, so I would suggest getting a table if your budget allows.
They bring in a lot of good talent to host and DJ - and they do play a lot more hip hop than other clubs here in Vegas, so it's a good spot if you are in to that.
Thursdays are the local industry night, and this is really the only night I've ever been. I try to avoid the Strip and nightclubs on weekends when all of the drunk, crazy tourists are out in force. :)
This is still one of my favorite places in town, and I suggest it to everyone. My only suggestion is to be careful of people who try to budge in on your table - there are lots of wannabes and cheap people who won't pay for their own table (especially girls) who try to drink your alcohol.