Despite being "local" now, I still really enjoy taking "staycations" on the Strip. Wynn is at the top of my list for places to spend the night.
They have some of the best clubs and lounges (Tryst and Blush) on the Strip and the rooms are amazing. The casino itself has a swanky feel that transcends any "theme."This place serves as a great retreat when you just want to get away and the service is always great.
The only possible drawback is that you really do have to pay for all of the above.