We love this place! We would visit more often if we lived or worked nearby (and weren't worried about our waistlines!)
The menu is a cornucopia of your typical Jewish deli / New York City delights. My personal favorites are the lox n' cream cheese sandwich and the "Radio City Smoothie" sandwich (goose liver) - the latter terribly, terribly bad for you but oh-so-good! On cold days their "cup" (size of a small bowl!) of matzo ball soup really hits the spot! They have a dessert counter you can't avoid as you walk in and out of the restaurant full of delectable treats you really shouldn't be looking at!
The main reason I like this place: wholesome ingredients! The food at Manhattan Deli - whether it's soup, sandwich, meat dish, or dessert - is rich in quality and flavor. Therefore, I don't mind paying the extra price for this premium food.
NOTE: Manhattan Deli is currently located next-door to Giant Eagle in the Chardon Bishop Plaza (shopping mall @ Chardon/6 and Bishop/84) but they have tentative plans to relocate to the Pine Ridge Plaza Shopping Center on Ridge Road/84 (near SOM Center Road/91).