The Great Lakes Brewery Brewpub. It's like trying to review Jerusalem or Mecca...but better.
Great Lakes has to have one of my favorite brewpubs in the country -- not just because their beer is worth writing home about everyday and twice on Sunday, but because one can feel the nostalgic and yet somehow timeless atmosphere of the building(s) almost immediately.
Situated right in Ohio City across from the West Side Market, the GLBC Brewpub is easily accessible from the downtown area -- and definitely worth the journey from the 'burbs. It's not a terribly large place -- so if it's busy, simply remember that good things come to those who wait.
I must say, I didn't expect to find one of the best burgers I've had in months...but I did...and it was amazing! My friend very much enjoyed her chicken sandwich as well. Our service was pretty good -- she was busy, but her knowledge of the beer more than compensated.
One thing I simply must note: I took one look at the beer menu and thought: "I really want to try this 'Cleveland Brown Ale'" -- only to be greeted by our server who said: "Really sorry, we're out of the Cleveland Brown Ale -- and oh-by-the-way we don't bottle it and don't sell it anywhere else". This was ~2 months ago and as I was only just visiting C-town, my pitty party is just now ending.
Bottom line -- unless you hate good food, despise great beer, and have no desire for a fun dining experience, there's no reason not to stop in and enjoy the Great Lakes Brewpub.