As brewpubs go, I think this is the best in Madison. The food is great, and the beer is very good. While I prefer the downtown location for its atmosphere and garden seating, the Fitchburg location is a bit more convenient for a west-sider and parking is never a problem.
All of the Great Dane standard beers are good, although I've tasted a few "misses" in their seasonal and special varieties (like the watermelon wheat, yuck), but favorite/stand-by is the Scotch Ale.
The Dane is on my list of "must visits" when friends and family come to town.