I love the Wynn Casino and Hotel! We've stayed at several places along the strip. The Wynn is definitely one of the best. Rooms are super comfy, casino is very nice and I've actually won on their slots so they aren't as tight as reported. The buffet is amazing.
Only challenge is it's so far north of most casino's it's not super convenient if you want to explore the rest of the strip. I keep hoping the north part of the strip will continue to be developed because if/when it does, the Wynn will be in a primo location.