Best night of the week is Friday night where all of the old and decrepit playas of Pittsburgh come out to drink. Wednesday and Thursday happy hours also decent. For Pittsburgh standards, it's a very swanky joint and the drink prices are decent (wait my SF pricing kicked in...ok it's a bargain!) I also agree with the other reviewer's sentiments about the food. Several steps up from your standard bar food in Pittsburgh, and the portions are HUGE for tapas.
To the ladies- this is the best joint in Pittsburgh to get your SATC mode on.