Every time I go to Vegas, I have to go to Quark's for a Warp Core Breach, ie: the fishbowl sized beverage which you are required to have a friend share with you. Also, it's in the Hilton, so you can go upstairs before and/or after your fishbowl and play some $2 blackjack.
The food is just meh, the onion rings are good, but it's really the drinks I always go for. We stopped here for a bachelorette party once and the bartender made us all these really fun shots (complete with bartender Flair) and bought us a few rounds, too.
Minus one star for the extremely in-character Star Trek actors who always either sneak up on me and scare the crap out of my drunk ass, or hit on me (what is the name of the pervy Star Trek character with big ears??), scaring the crap out of my drunk ass.