Definitely a recommend just for the awesome alien spaceship chandelier! Reminded me of Independence Day inside the club.
Omnia definitely feels like a newer club and doesn't feel as seedy or cramped as other clubs I've visited like Tao. The dance floor got too crowded for us and we ended up just saying along the perimeter while waiting for Nervo. The music here was ear-splitting and I actually bought in my own concert-specific earplugs while everyone else in my party wadded up napkins to stick in their ears. Granted, losing some hearing is probably part of the clubbing experience, but it's not for me anymore =).
Besides the main room definitely check out the Heart Room for some more old school non-EDM music and the outdoor terrace to check out views of the Strip!