I have the biggest girl crush on the House of Blues. Like, if it were a person, I would ask it on a date. Maybe I'm totally sheltered? Because I think this is the best venue EVER to see a concert.
There isn't a bad seat in the house. If you aren't into getting punched in the face by random strangers, you can chill out upstairs and still have a good view. If you aren't a marathon stander, you can (usually) get seats and have a great view. Really, I think it's a perfect venue. The sound is always great.
My favorites shows have been at the House of Blues - maybe I'm biased. But I think given the prices of tickets and the quality of the sound and the size - you can't go wrong with the HOB.