Just like any other upscale Vegas clubs, it is a whole lot easier being a girl and having no guy in your group.
Went there twice. First time I came here (at the recommendation of a cab driver), there were three guys and one other girl in my group. We were told to line up with everyone else and it took us more than an hour to get in. Next time I was in here, I was with two other ladies and we walked right in 5 minutes after talking to the bouncer.
Nonetheless, the experience was worth the wait (if I had to). The bouncers, although strict with the guy:girl ratio, were never less than courteous. Once you walk in, there was a row of water-filled tubs with girls in it. The interior is Buddhist / Asian inspired and the dark wood must've made it less tacky. The restroom is amazing - the see-through glass door immediately turns opaque as soon as you lock the door.
Guys - pay for a table service, stay at the Venetian, or get a hookup!