The Drake General Store has long intrigued me, mostly because Toronto Life always seems to find little gems for their "fun and funky" gift sections in their rag.
They have an interesting mix of kitsch: things like RCMP-printed napkins, Popeye candy cigarettes, crazy coloring books, and lots of cool cards. They do, though, carry Marvis Mint Jasmine toothpaste, something I haven't been able to find anywhere else in Toronto. Score!
Their wares are definitely more expensive than your average gift shop. I'm sure that's a combination of it being the Drake and the uniqueness of their stuff. Price notwithstanding, the Drake General Store is a cool place to pop in when you need that really cool thing to impress the VIPs in your life.