Use them at your & your pet's own risk. I received a refill and my dog started having symptoms unrelated to her disease or possible side effects. Two vets have confirmed that it seems like a drug reaction to something other than the drug she is SUPPOSED to be on. Luckily, my vet has agreed to send the prescription to another pharmacy. I will never ever use them again. They said that were going to research into a bad lot of medication, never to here from them again