Two of our friends brought my fiance and I to E2 as a treat when we visited Pittsburgh. It was a beautiful day, and we got to sit outside and sip on some BYOB wine. The staff was so sweet, and even opened up our bottle of wine while we waited. The porcinni was to die for, as was the ravioli. At some point we decided to go family style because we wanted a taste of every item. Even if you're full, get the beignets.
We were so impressed with E2, we looked into having our rehearsal dinner there, but it books up quickly for big events. The only negative would have to be the location, as there's not as much to do in the area.