Espresso a Mano seems to be the top rated cafe in Pittsburgh and with good reason. My roommate and I stopped here for breakfast on a cross country drive yesterday and I was expecting it to be good but I was still impressed.
The staff are fast and friendly and clearly care about what they do. I ordered a chai latte and got latte art on it without even requesting it. It was slightly heavy on the cinnamon for my taste on its own, but I had it with one of their croissants which balanced out the flavor well. I think they must make them themselves or get them from a local bakery because they're richer in flavor than your typical croissant and not hard or dry either. My friend also loved his coffee.
Atmosphere is open and clean and not annoyingly loud or busy. When we visit Pittsburgh again we'd love to come back.