The Rio is a nice hotel. They have some of the sexiest cocktail servers (men and women). The only casino that I know of with male cocktail servers for the ladies.
Though they're away from the strip there is plenty to do here. They have a free shuttle to either Harrahs or Balleys on the strip. The shuttle runs about every 30 minutes until 1:00am.
There is Voodoo Nightclub. A rooftop nightclub with an amazing view. One DJ outside and one DJ inside.