See my review for Myst because much of that applies here - however, Axis/Radius is of course a little different... This is a bit more of a meet market than Myst and there's more space to dance if that's your thing - that doesn't mean there's more room... it's actually more difficult to dance here because it's more crowded on a busy night.
This place has been around longer than most clubs in the valley and it has managed to keep somewhat busy. The fact that it's been around for so long should demonstrate how solid it is. I'm not a huge fan of clubbing and I don't even really like to go to Myst or Axis/Radius - however, I recognize that these places do a good job at what they do. I have even had a decent time at these clubs before.
One of the benefits of going to one of these larger clubs is that the douche-factor is lower than at the smaller trendy clubs. The 'who's who' are far too snobby to show their faces here. You're also likely to meet someone from out of town here.