Absolutely the best in the 'Burgh. Everything about this pizza is perfect. They put on a ton of cheese, so you really don't need to get extra cheese here. I tend to prefer white pizza at other shops, but Mineo's sauce is so good I opt for the red. If hoagies are your thing, the vegetarian clyde special is really really good.
When you're done eating the pizza/hoagie, stop at the extra dining room and pick up some Prantl's burnt almond torte.