One of my all-time favorite restaurants to go to in downtown Pittsburgh. Their menu has a very nice selection of food. Everything from fancy corn dogs to marrow (I have not yet tried the marrow, but some of my family has and they really enjoyed it). The atmosphere in the restaurant is quite nice, though the lighting is quite dark so if some people have trouble with that do be aware. The cocktails available at Meat and Potatoes are also phenomenal. I personally really enjoy their barrel-aged Manhattans; I don't know the last time I had a Manhattan that good.
Do be warned, you are most likely going to want a reservation, as it gets quite crowded, and you might otherwise have to wait.