My favorite hotel in Vegas is the Encore. Everything about our stay was excellent. I think the Encore has the best, most comfortable beds in town.
Although a bit smaller than the Wynn, this makes the lay-out of the resort easier to remember. I like that you can walk out onto the strip to get to the Fashion Show Mall, or walk through the Wynn. Encore is a little more grown-up than the Wynn -- not quite as whimsical, but elegant, polished and chic.