The Overture Center is a very nice venue. I've been to the Madison Symphony Christmas concert for five years in a row. I've also seen Louie C.K. at the Overture Center (prior to his sexual harassment PR problem).
I've sat in several different areas of the Overture Center, but I'd say the box seats at the circle and mezzanine levels are my favorite. I personally like the box seats because I get my own chair and my own space. I'm not sandwiched in between hordes of people in a box seat like I would be in the regular seats.
Once you approach the balcony regular seats and/or box seats in the balcony level, you're so high up that it can be hard to make out the faces of the people on stage. That's probably okay for an orchestra performance, but I prefer to have a closer view for a headliner like a comedian.
While it's easy to think that closer is always better, I would suggest otherwise when it comes to box seats on the orchestra (floor) level. I purchased those box seats for the 2017 Christmas concert, and I could barely see much of the stage because I watched the organist's back the entire time. While my seat was literally three feet away from the organist, the view was not good. Furthermore, the sound didn't seem to project as well as I remember other concerts where I sat higher and farther away from the stage. For the best acoustics and the best view, you're better off avoiding the very front -- front center or front side -- at the Overture Center. Get back just a little bit and move just a little higher.
The venue is always pretty and very clean. The concourses are big enough that there's not much congestion. There are plenty of bathrooms, and I don't think I've ever found myself in a line at the bathroom. Parking is very easy if you park in the Overture Center garage. You have to walk just about a block.
It's a great venue!